Figure 6 from Tumor-Associated Platelets Suppress T-cell Function and Promote Immune Evasion in TNBC via the P-selectin/P-selectin Glycoprotein Ligand 1 Pathway
Year: 2026
Type: other
Abstract: Inhibition of P-selectin increases response to anti–PD-1 in tumor cells. A, Tumor volume measurements of mice injected with either AT-3 or EO771 cells that received a combination of RB40.34 and anti–PD-1. Flow cytometry was used to measure functionally active (B) CD4+ and CD8+ effector T cells cocultured with RB40.34 and anti–PD-1, exhaustion of (C) CD4+ and CD8+ effector T cells cocultured with RB40.34, and (D) Tregs. Data are representative of two independent experiments. Statistical significance was determined using a one-way ANOVA followed by the Tukey multiple-comparison test. ns, not statistically significant; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7167889220