Evaluation of phytochemicals and acid-neutralizing properties of aqueous leaf extracts from croton Megalocarpus, Ipomoea batatas and Carica papaya used as complimentary treatment for peptic ulcers and as antacids by some communities in Kenya
Year: 2026
Type: article
Abstract: Hypersecretion of gastric acid damages the stomach lining, causing the formation of peptic ulcers. Medicinal plants offers a relaxing and soothing effect to the endodermal lining of the gut and has antacid properties, which can protect the mucosal lining from gastric acidity. This research aimed to evaluate the phytochemical properties acid-neutralizing properties of traditionally used aqueous leaf extracts from Croton megalocarpus, Ipomoea batatas and Carica papaya. The phytochemical properties were determined by biochemical methods. Acid neutralizing and buffering capacities were determined by titration methods. The phytochemical characterization of the aqueous leaf extracts confirmed the presence of carbohydrates, alkaloids, saponins, tannins, flavonoids, and glycosides. The phytochemical analyses did not show the presence of fat/oils, and proteins in the leaf extracts of the three plants. Croton megalocarpus plant leaf extract exhibited the most potent artificial gastric juice neutralizing capacity pH of 5.33±0.01, 9.71±0.01 acid neutralization capacity per gram of acid, and 15 minutes duration of acid neutralization compared to Ipomoea batatas (4.41±0.01) and Carica papaya (3.88±0.01). Calcium carbonate (positive control) had the highest acid- neutralizing capacity (6.73±0.01). The combined leaf extracts also had remarkable acid-neutralizing capacity 5.16±0.00 and acid neutralization capacity per gram of acid of 8.90±0.00. These findings revealed that Croton megalocarpus, Ipomoea batatas and Carica papaya have the potential to neutralize gastric acid responsible for ulceration. More research is recommended to establish their mechanisms of action, dosage and safety.
Author: Kiptisia T Richard
Institution: University of Eldoret
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7168034800