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Synthesis, Spectral Studies and Physical Characterisation of Some Novel Morpholine Derivatives

Year: 2026

Type: article

Abstract: Novel morpholine derivatives are synthesized through multi-step reactions often involving morpholine with alkyl halides, aldehydes, or acid chlorides to form Schiff bases, hydrazides, or cyclic analogues, yielding high-purity compounds confirmed via spectroscopic methods. Spectral studies typically include ¹H NMR, ¹³C NMR, FT-IR and mass spectrometry to assign structures, revealing characteristic morpholine ring protons around 2.4-4.0 ppm, carbonyl stretches at 1650-1700 cm⁻¹ and molecular ions matching calculated masses. Physical characterizations involve melting points (often 120-200°C for solids), elemental analysis (CHN), and solubility in polar solvents like DMSO or ethanol, with many showing biological potential like Antibacterial and analgesic activity.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.21357167

Author: Dr. P. R. Logeshkumar*1, Dr. S. K. Senthilkumar2, S. Jeevitha3, C. Kamalesh3, Pa. Kamaliya3, S. Kamalraj3, M. Karthikeyan3

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W7168248273

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