Work

On target? Cardiovascular risk factor patterns in type 1 and type 2 diabetes: real-world attainment of cardiovascular risk factor targets and medication prescriptions

Year: 2026

Type: article

Abstract: AIMS: Adequate cardiovascular risk control prevents complications. A multifactorial approach for simultaneously managing risk factors is recommended by guidelines. We evaluated cardiovascular risk factors among Dutch diabetes outpatients and described glucose-lowering and cardiovascular prescriptions. METHODS: From the Dutch Pediatric and Adult Registry of Diabetes (DPARD), a cohort of 81,096 patients with type 1 diabetes (T1D) or type 2 diabetes (T2D) was derived from 2017 to 2024. Descriptive statistics reported patient characteristics and the primary outcomes cardiovascular risk targets and medication prescription patterns. RESULTS: Overall, 3,832 children had T1D, 145 children had T2D, 35,934 adults had T1D and 41,185 adults had T2D. For most cardiovascular risk factors, guideline-recommended targets were met by at least two-thirds of patients, whereas some risk factors had lower attainment in specific subgroups. HbA1c was the least frequently reached target. The most common medications for T1D were fast-acting and long-acting insulins. For T2D, these were biguanides, insulins, sulfonylureas, GLP-1 agonists, and SGLT2 inhibitors. CONCLUSIONS: This study shows the extent to which guideline-recommended cardiovascular risk factor targets are met in children and adults with T1D and T2D, which varies by age group and diabetes type. These findings may refine individually tailored strategies for management of risk factors, particularly HbA1c.

Source: Diabetes Research and Clinical Practice

DOI: 10.1016/j.diabres.2026.113440