Patient-specific determinants of lens dose in sinonasal carcinoma radiotherapy: role of age, sex and gaze direction
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: This study aimed to analyse the influence of age, sex, and gaze direction on lens dosimetric parameters during sinonasal carcinoma radiotherapy. Materials and methods: . female categories. Lens movement amplitude and corresponding dosimetric parameters were assessed across different gaze directions. Average and maximum amplitudes of movement, along with corresponding dosimetric parameters, were quantified. Results: Lens movement was significantly affected by gaze direction, with the largest displacement (0.96 ± 0.62 mm) observed in the caudal direction. Lens displacement resulted in an average increase of 2.84% ± 6.42% (range: -7.45% to 18.18%) in mean dose and 2.87% ± 8.00% (range: -17.21% to 31.42%) in maximum dose. Dose parameters at extreme gaze positions were significantly higher compared with the average lens position. No significant differences were observed between male and female groups. However, age was significantly correlated with lens dose parameters but not with displacement across gaze directions. Conclusions: Lens dose parameters were significantly influenced by age and gaze direction, but not by sex. Lens movement during routine treatment sessions was less pronounced than previously reported, suggesting that earlier studies may have overestimated lens dose. Incorporating patient-specific factors, particularly age and gaze direction, may help avoid excessive doses and mitigate the risk of radiation-induced cataract in sinonasal carcinoma radiotherapy.
DOI: 10.5603/rpor.113322
Language: English
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,713
OpenAlex ID: W7168264913