Non-fasting and Fasting Triglyceride Levels and the Risk of Diabetes Mellitus: The Circulatory Risk in Communities Study
Year: 2026
Type: article
Study design: Observational Study
Abstract: AIMS: Non-fasting triglyceride measurements have become increasingly common in screening for atherosclerotic cardiovascular disease. However, evidence of its predictive value for diabetes mellitus is limited to only a few studies. METHODS: This prospective cohort study included two groups of individuals aged 40-74 years without diabetes mellitus: 7,673 who provided non-fasting blood samples and 4,055 who provided fasting samples. We used annual health checkup data to identify new cases of diabetes mellitus, employed Cox proportional hazard models to estimate hazard ratios, and conducted decision curve analyses to assess clinical utility. RESULTS: During a median follow-up of 13 years, 727 and 444 participants were diagnosed with diabetes mellitus in the non-fasting and fasting groups, respectively. After adjusting for the glucose levels and other potential confounders measured at baseline, both non-fasting and fasting triglyceride levels were positively associated with the hazard of diabetes mellitus; the hazard ratios (95% confidence intervals) for the highest versus lowest quartiles were 1.99 (1.50-2.64) and 1.58 (1.11-2.26), respectively. Adding non-fasting or fasting triglyceride levels to a model based on traditional predictors can slightly improve the net benefit for 15-year risk prediction, corresponding to an approximate gain of 1 to 2 additional individuals per 1,000 screened. The improvement was slightly greater under non-fasting conditions than under fasting conditions. CONCLUSION: Both the non-fasting and fasting triglyceride levels were associated with an increased hazard of diabetes mellitus. Adding the triglyceride levels can therefore provide modest but potentially useful supplementary information for diabetes prediction, particularly under non-fasting conditions.
DOI: 10.5551/jat.66064
Institutions: Kindai University, University of Tsukuba, Juntendo University, Research and Development Center for Health Services, University of Tsukuba, Yao City Health Center, Osaka Institute of Public Health, Fukushima Medical University, Dokkyo Medical University, Osaka Center for Cancer and Cardiovascular Disease Prevention, Japan Institute for Health Security
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: A cohort study on risk factors for carotid atherosclerosis and prediction of cardiovascular risk, Study on new risk factors for prevention of stroke and coronary heart disease in uged populations, Associations of Psychological Factors with Inflammation, Metabolic Disorder, and Autonomic Function, Epidemiologic study on new risk factors for progression of atherosclerosis, Epidemiology and moleculorbiology on emvircnemnted and genetic factors for atheis sclirosis and thrombasis, The extent of arteriosclerosis in multiple vessel bedsand their risk factors among urban Japanese residents, A large-scale epidemiological study on the association between metabolism biomarkers and the incidence of cardiovascular diseases, 地域におけるインスリン抵抗性、耐糖能異常、糖尿病に対する健康教育技法の開発と評価, Recent change of Risk factors of Ischemic Cordio-and Cerebrovasular Diseases, Epidemiological study on carotid atherosclerosis and it related factors for the prevention of cardiovascular disease
OpenAlex ID: W7168282890