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High resolution full-length 16S rRNA gene sequencing reveals distinct fecal microbial consortium associated with colorectal cancer in Saudi Arabia

Year: 2026

Type: article

Abstract: = 1.71%, BH-FDR-adjusted q = 0.049). Differential abundance analysis identified Fusobacterium animalis as a CRC-specific species, undetectable in healthy cohorts. Species-level co-occurrence network analysis further demonstrated positive associations among F. animalis, Peptostreptococcus stomatis, Dialister pneumosintes, and Parvimonas micra. These anaerobes, typically recognized as oral bacteria, formed a tightly connected consortium unique to patients with CRC but absent in healthy cohorts. These results suggest a CRC-specific microbial signature with potential utility as a non-invasive biomarker for early detection. Future multi-omics studies are warranted to support the development of microbiota-based diagnostics for CRC management.

Source: Scientific Reports

DOI: 10.1038/s41598-026-62044-x