Development and Validation of RP-HPLC Method for Simultaneous Estimation of Dapagliflozin and Bisoprolol in Bulk and Pharmaceutical Dosage Form
Year: 2026
Type: article
Abstract: The assay of Dapagliflozin & Bisoprolol was performed with tablets and the % assay was found to be 100.10 & 100.08% which shows that the method is useful for routine analysis. The linearity of Dapagliflozin & Bisoprolol was found to be linear with a correlation coefficient of 0.999 and 0.999, which shows that the method is capable of producing good sensitivity. The acceptance criteria of precision is RSD should be not more than 2.0% and the method show Intraday and Inter-day precision 0.13 and 0.30 % for Dapagliflozin and Intraday and Inter-day precision 0.13 and 0.30 % for Bisoprolol. which shows that the method is precise. Which shows that the method is repeatable when performed in different days also. The total recovery was found to be for Dapagliflozin is 99.45-100.58 % and for Bisoprolol is 99.66-100 %. The validation of developed method shows that the accuracy is well within the limit, which shows that the method is capable of showing good accuracy and reproducibility.
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W7168528134