Work

Nanofibrous Materials and Nanoparticles for Combating Antimicrobial Resistance: Synthesis, Integration, and Translational Perspectives

Year: 2026

Type: article

Abstract: Antimicrobial resistance (AMR) is a major global health challenge driven by mechanisms such as biofilm formation, efflux pumps, and genetic mutations. Nanoparticulate and fibrous materials have emerged as promising strategies to overcome these limitations through multimodal antimicrobial action and controlled drug delivery. This review highlights recent advances in electrospun nanofibrous systems, including natural and synthetic polymer-based scaffolds, stimuli-responsive nanofibers, and functionalized patches. Nanoparticle-loaded nanofiber systems demonstrate enhanced performance, including bacterial eradication, sustained drug release, and significant biofilm disruption. Multifunctional systems combining antimicrobial, antioxidant, and immunomodulatory properties further show synergism. Emerging innovations, such as piezoelectric and smart sensing systems, enable self-powered antimicrobial activity and real-time infection monitoring with high detection accuracy. The nanostructured systems reported in this review provide a versatile and effective strategy for combating AMR.

Source: ACS Biomaterials Science & Engineering

DOI: 10.1021/acsbiomaterials.6c00880

Authors: Rewati Raman Ujjwal, Ashish Dilip Sutar, Rahul Shukla, Gymama Slaughter

Institutions: National Institute of Pharmaceutical Education and Research, National Institute of Pharmaceutical Education and Research, Old Dominion University

Language: English

Topic: Electrospun Nanofibers in Biomedical Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500