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Large increases in resistance training volume do not impair muscle hypertrophy or anabolic-catabolic molecular signaling in trained individuals

Year: 2026

Type: article

Abstract: A large, abrupt increase in weekly resistance training volume (+120% relative to habitual training) did not enhance muscle hypertrophy compared with a modest increase (+20%) in resistance-trained individuals. We found no evidence that the larger volume progression attenuated adaptation under the present experimental conditions. Acute and chronic molecular responses likewise did not differ significantly between protocols.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00284.2026

Authors: Júlio B. B. Camargo, Diego Bittencourt, J. Max Michel, Deivid G. Silva, João G. A. Bergamasco, Alexander C. Berry, Dakota R. Tiede, Dustyn Lewis, Enya T. A. Nacafucasaco, Otávio Ferrari, Ana C. C. Melo, Matheus Iasulaitis, Marcelo Rebelatto, Michael D. Roberts, Cleiton A. Libardi

Institutions: Universidade Federal de São Carlos, Florida Institute for Human and Machine Cognition, Auburn University

Language: English

Topic: Muscle metabolism and nutrition

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico

Awards: G2932511526, G3355623685, G5470024535, G8028795708, G8668448699

OpenAlex ID: W7168804546

FWCI:

Cites: 71

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