Work

Growth of PIK3CA-driven cerebral cavernous malformations does not require microbiome stimulation

Year: 2026

Type: article

Abstract: We find that the microbiome plays a critical role in the formation of cerebral cavernous malformations in neonatal but not adult life.

Source: JCI Insight

DOI: 10.1172/jci.insight.208733

Authors: Lun Li, Rhonda Lightle, Bader Ali, Georgeio Sader, Robert Shenkar, Sean P. Polster, Douglas A. Marchuk, Jan-Karl Burkhardt, Issam A. Awad, Mark L. Kahn

Institutions: Hospital of the University of Pennsylvania, University of Pennsylvania, University of Chicago, University of Chicago Medical Center, Duke University

Language: English

Topic: Vascular Malformations Diagnosis and Treatment

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,100

Funders: University of Pennsylvania, Fondation Leducq, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke

Awards: Heg-CCM Signaling in Cardiovascular Development and Disease, Vevo 2100 Imaging System, Signaling Aberrations and Cerebral Cavernous Malformation Pathogenesis, TLR4 and the microbiome in CCM disease

OpenAlex ID: W7168913342

FWCI:

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