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It's more than mechanics: the case for metabolic end-points in airways disease

Year: 2026

Type: article

Abstract: Extract Metabolic dysfunction, including insulin resistance and hyperglycaemia, has been found to contribute independently to airway inflammation, impaired lung mechanics, and altered immune responses in the lungs (figure 1). [1–7] Insulin resistance and compensatory hyperinsulinaemia can directly alter airway biology, including promoting airway smooth muscle proliferation and contractility, airway hyperresponsiveness, impaired beta-agonist responses, airway remodelling and inflammation.

Source: European Respiratory Journal

DOI: 10.1183/13993003.01007-2026

Authors: Chloe I. Bloom, Dinah Foer, Vanita R. Aroda, Katherine N. Cahill

Institutions: Imperial College London, Brigham and Women's Hospital, Harvard University, Vanderbilt University Medical Center

Language: English

Topic: Asthma and respiratory diseases

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7168918304

FWCI:

Cites: 51

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