Work

Three-dimensional Mapping of Fibrosis Distribution in Desmoplakin Cardiomyopathy from Cardiac MRI

Year: 2026

Type: article

Study design: Observational Study

Abstract: Use of universal ventricular coordinates to integrate information from cine and late gadolinium enhancement cardiac MRI enabled generation of high-resolution fibrosis maps and revealed distinct spatial patterns across disease severity in desmoplakin cardiomyopathy.

Source: Radiology Cardiothoracic Imaging

DOI: 10.1148/ryct.260010

Authors: Javiera Jilberto, Brennen McManus, Ahmad Moghrabi, Prachi Agarwal, Eric D. Smith, Adam S. Helms, David Nordsletten

Institutions: University of Michigan, Stanford Medicine, Stanford University, Michigan Medicine

Language: English

Topic: Cardiomyopathy and Myosin Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, Fulbright Chile, Agencia Nacional de Investigación y Desarrollo, National Institutes of Health

Awards: Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET, G5043199207, Cis regulatory variants of haploinsufficiency genes as cardiomyopathy modifiers, Multi-Scale Systems Analysis of Metabolic and Mechanical Determinants of Reserve Cardiac Power Output, Dissection and Rescue of Mechanical and Transcriptional Defects in Desmoplakin Cardiomyopathy

OpenAlex ID: W7168947515

FWCI:

Cites: 17

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