Sex-divergent skeletal muscle remodeling emerges early in cancer cachexia
Year: 2026
Type: article
Abstract: By modeling cancer-associated cachexia over a time-course in male and female mice, we show that skeletal muscle remodeling begins before overt wasting is evident. The precachectic interval is marked by suppressed protein synthesis, muscle-local immune remodeling, extracellular matrix disruption, and metabolic vulnerability, with several responses differing by sex. These findings suggest that key features of cachexia emerge early in the disease time-course and may inform clinical approaches for detecting disease before significant muscle wasting occurs.
Authors: Chris Karagiannis, Alastair A. E. Saunders, Rachel E. Thomson, María Guillán-Fresco, Wayne X. Du, Craig A. Goodman, Paul Gregorevic
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7168988417