Differential lung injury after permanent and transient focal cerebral ischemia in rats
Year: 2026
Type: article
Abstract: By comparing permanent and transient focal cerebral ischemia, this study reveals that the duration of stroke determines secondary pulmonary outcomes. Permanent ischemia induced pronounced lung tissue injury, inflammation, edema, and impaired tissue mechanics, whereas transient ischemia with reperfusion largely preserved lung structure and function. These findings identify the temporal dynamics of cerebral ischemia as an important modulator of brain-lung interactions and suggest that limiting ischemic exposure may attenuate stroke-associated pulmonary complications.
Source: Journal of Applied Physiology
Institution: University of Szeged
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funder: Hungarian Science Foundation
Award: G5637594917
OpenAlex ID: W7169036382