Work

Successful Endoscopic Submucosal Dissection for Primary Esophageal Mucosa‐Associated Lymphoid Tissue Lymphoma

Year: 2026

Type: article

Abstract: ABSTRACT Primary esophageal extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue (MALT lymphoma) is extremely rare, and its optimal management has not been established. We report a case of primary esophageal MALT lymphoma that was successfully treated by endoscopic submucosal dissection (ESD). A 70‐year‐old woman presented with an elevated lesion in the lower esophagus that was detected incidentally on computed tomography. Endoscopy and endoscopic ultrasonography revealed a subepithelial lesion confined to the submucosal layer without apparent invasion of the muscularis propria. Although an endoscopic biopsy suggested a low‐grade lymphoma, a definitive diagnosis could not be established because of the limited tissue volume. Therefore, ESD was performed to obtain an adequate specimen for definitive diagnosis, and complete resection was achieved as a result. Histopathological and immunohistochemical examinations of the resected specimen confirmed primary esophageal MALT lymphoma. The patient has remained in complete remission for 3 years without additional therapy. This case suggests that ESD may be a diagnostic and therapeutic option for primary esophageal MALT lymphoma. Trial Registration : N/A.

Source: DEN Open

DOI: 10.1002/deo2.70384

Authors: Junya Makiyama, Hiroko Fukuda, Kyoko Minamino, Yukiyoshi Moriuchi, Koichi Ohshima

Institutions: Sasebo City General Hospital, Nagasaki University Hospital, Kurume University

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500