Work

Impact of acute mild and severe poikilocapnic hypoxia on dynamic cerebral autoregulation and its directional sensitivity in young healthy volunteers

Year: 2026

Type: article

Abstract: Using a multimetric approach combining transfer function analysis with directional sensitivity metrics, we demonstrate that severe, but not mild, poikilocapnic hypoxia impairs dynamic cerebral autoregulation, whereas preserving its directional sensitivity across oxygen levels. These findings suggest that distinct mechanisms govern the dynamic and directional components of dynamic cerebral autoregulation.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00166.2026

Authors: Shahrzad Soleimani Dehnavi, Marc-Antoine Roy, Mahmoudreza Taghizadeh, François Billaut, Patrice Brassard

Institutions: Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval

Language: English

Topic: High Altitude and Hypoxia

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Natural Sciences and Engineering Research Council of Canada, Fonds de Recherche du Québec - Santé