Tacrolimus-resistant regulatory T cells: Combining the best of both worlds?
Year: 2026
Type: article
Abstract: The advancement of adoptive cell therapy has changed perspectives in solid organ transplantation. Immunosuppressive maintenance therapy in transplantation efficiently prevents allograft rejection, but is the main driver of cardio-metabolic complications, death caused by infections, malignancies, and cardiovascular disease.1,2 Minimization strategies for immunosuppression however are not unlimited and not without risk.3 Early phase 1/2a studies indicate that adoptive transfer of autologous Tregs in de novo living donor kidney allograft recipients is safe and enables reduction of triple-drug immunosuppression to low-dose tacrolimus monotherapy in the majority of patients.
Source: Molecular Therapy Advances
Author: Dirk Kuypers
Institution: KU Leuven
Language: English
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7169079602