Hyperoxic cerebral vasoconstriction in healthy humans: global, lobe, and regions of interest
Year: 2026
Type: article
Abstract: This study demonstrates that acute isocapnic hyperoxia induces widespread cerebral vasoconstriction, reflected by reduced cerebrovascular conductance. Contrary to the hypothesis, the vasoconstrictive responses appear spatially uniform across lobes and regions of interest (ROIs), although the ROI conclusions are preliminary. These findings refine regional understanding of hyperoxia-induced cerebrovascular regulation and underscore the importance of considering vascular conductance, rather than CBF alone, when evaluating the cerebral effects of supplemental oxygen.
Source: Journal of Applied Physiology
Institution: University of Wisconsin–Madison
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Award: G7741932817
OpenAlex ID: W7169142120