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Regulator-Guided Strain Prioritization and Genome Engineering Uncovers Concanamycin Analogs

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Year: 2026
Type: article
Source: Journal of Natural Products
DOI: 10.1021/acs.jnatprod.6c00590
Authors: Linnea Verhey-Henke, Katherine L. Lev, Morgan McCauley, Nirmal K. Chaudhary, Natalia R. Harris, Salika Safar, Jackson R. Rapala, Teresa R. O’Meara, David H. Sherman, Filipa Pereira
Institution: University of Michigan
Language: English

Topic: Microbial Natural Products and Biosynthesis
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences

Open Access status: closed

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases
Awards: G1077869373, G4586057094, Viper-active: Snake Venom Microbiome as a Source for Bacterially-derived Molecule Discovery, G8967419206, Discovery of gene function and dissection of network re-wiring in non-model fungi, Exploiting microbial regulatory networks to accelerate natural products discovery
OpenAlex ID: W7169163948
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Cites: 41
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