Work

Diacarnusins A-F, nor -Terpene Endoperoxides of the Red Sea Sponge Diacarnus erythraeanus

Year: 2026

Type: article

Abstract: Six new nor-terpene endoperoxides, diacarnusins A-F (1-6), along with five known ones (7-11), were isolated from the extract of the Red Sea sponge Diacarnus erythraeanus, which presented cytotoxic activity against the colon carcinoma cell line. The structure elucidation was performed by analysis of mass spectrometric and 1D and 2D NMR data. The relative and absolute configurations of the stereocenters of the compounds were deduced based on the Capon and Macleod empirical rule and comparison of the sign of their specific rotations with those of endoperoxides with proven absolute configurations. The cytotoxicity of the pure compounds was evaluated against a panel of cancer cell lines. The structure elucidation and biological activity of the compounds are discussed.

Source: Journal of Natural Products

DOI: 10.1021/acs.jnatprod.6c00510

Authors: Rania Hasib Afana, Lilach Raijman-Nagar, Micha Ilan, Shmuel Carmeli

Institution: Tel Aviv University

Language: English

Topic: Marine Sponges and Natural Products

Subfield: Biotechnology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500