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Solubility Enhancement Technology: Liquisolid Compact

Year: 2026

Type: article

Abstract: Poor aqueous solubility remains one of the major challenges in the development of effective oral drug delivery systems, particularly for drugs belonging to Biopharmaceutical Classification System (BCS) Class II and IV. Inadequate solubility often leads to reduced dissolution rate and low bioavailability, ultimately affecting therapeutic efficacy. Among the various approaches developed to overcome this limitation, the liquisolid compact technique has emerged as a simple, cost-effective, and efficient method. The liquisolid compact system involves the transformation of liquid medications or drug solutions into dry, non-adherent, free-flowing, and compressible powder mixtures by blending with suitable carrier and coating materials. This technique enhances drug dissolution by increasing surface area, improving wettability, and enhancing the apparent solubility of the drug.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.21407554

Author: Kazi Arbaz Mohmed Aasif, Dr. Nidhi Chauhan*, Hemangi Patel, Khushali Rathod, Nirav Vasava

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7169504685

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