Work

Engineered Bacteroides thetaiotaomicron for Targeted Elimination of Fusobacterium nucleatum and Prevention of Colorectal Cancer

Year: 2026

Type: article

Abstract: The S100 Therapeutic Pill is a novel engineered Bt-based therapeutic for targeting F. nucleatum and preventing colorectal cancer. The design includes 4 genomic edits: pyrE deletion (uracil auxotrophy), tdk replacement with SQR/FRD operon (H₂S detoxification), dnaE TAG at codon #2 (ncAA auxotrophy), and ompA thinning (hypervesiculation). The pill formulation includes sodium fumarate, uracil, and a non-canonical amino acid, with a pH-responsive coating for colonic release. Absolute biocontainment with 10⁻³² escape probability. Inventor: Andrei Valentin Irimia, Rădăuți, Romania. DOI: 10.5281/zenodo.21414869.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.21414895

Author: Irimia, Irimia Andrei Valentin

Language: English

Topic: Cancer Research and Treatments

Subfield: Biotechnology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7169532767

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