Work

Nanotheranostics for alcohol-related liver disease: advances in precision diagnosis and targeted therapy

Year: 2026

Type: article

Abstract: ABSTRACT: Alcohol-related liver disease remains a major and growing global health concern, with limited diagnostic and therapeutic options, particularly in advanced stages. Conventional diagnostic methods, including serum biomarkers, imaging and biopsy, often lack the sensitivity, specificity or practicality required for early detection and monitoring. Nanotheranostic platforms offer both targeted drug delivery and real-time assessment of disease activity. Organic, inorganic, polymeric and hybrid nanoparticles are being developed to improve the bioavailability and hepatic targeting of antioxidant, antifibrotic and RNA-based therapies. The use of novel nanodiagnostic probes and exosome-based assays enables the detection of early molecular alterations. However, delivery barriers and potential hepatotoxicity remain key translational challenges.

Source: Singapore Medical Journal

DOI: 10.4103/singaporemedj.smj-2025-271

Authors: Arielle Xin Yi Tay, Shridhar Ganpathi Iyer, Tiing Leong Ang, Han Kiat Ho, Dinesh Kumar Srinivasan

Institutions: National University of Singapore, National University Hospital, National University Health System, Changi General Hospital

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7169536172