Which Molecule Is Involved in the Nitrosation Reaction of Pharmaceuticals: NO or NO2?
Year: 2026
Type: article
Abstract: We have previously clearly identified atmospheric nitrogen oxides (NOx) as a key factor in nitrosamine contamination in pharmaceuticals. To implement more appropriate countermeasures, the nitrosation potential of nitrogen monoxide (NO) and nitrogen dioxide (NO2)─the primary components of NOx─was evaluated using short-term and long-term gas flow model experiments. The results revealed that NO2 is required for the nitrosation reaction to occur.
Authors: Ryota Nomura, Hideyuki Sogo, Takuma Onai, Misako Iwazawa, Tomohiro Kaku, Osamu Uchikawa
Institution: Towa Pharmaceutical (Japan)
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W7169570198