Work

Design, Synthesis, and Biological Evaluation of a Cathepsin B-Activated Small Molecule-Drug Conjugate Targeting AKR1C3 to Enhance Chemotherapeutic Selectivity

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.6c00881

Authors: Xiaolong Wang, Can Guo, Yimeng Liu, Bingjie Han, Lu Zhang, Zongliang Liu, Yao Chen, Haopeng Sun

Institutions: China Pharmaceutical University, Yantai University, Nanjing University of Chinese Medicine

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Natural Science Foundation of Jiangsu Province, Yantai Science and Technology Bureau, “333 Project” of Jiangsu Province

Awards: G2912324875, G39755173, G7459744271, G7555771726

OpenAlex ID: W7169657268

FWCI:

Cites: 34

Cited by:

Related to: