Work

Six weeks stretching of lower limbs lowers blood pressure in hypertensive individuals

Year: 2026

Type: article

Abstract: Purpose Previous studies on healthy subjects suggest that 6-week passive stretching (PS) lowers blood pressure (BP) and arterial stiffness by enhancing vascular responsiveness in both stretched and non-stretched arteries. This study investigated whether a similar 6-week PS intervention applied to the lower limbs could elicit similar effects in patients with essential hypertension. Methods 24 patients underwent assessments of central arterial stiffness (carotid–femoral pulse wave velocity, PWV cf ), brachial (systemic) and femoral (local) vascular responsiveness (flow-mediated dilation, FMD; nitrate-mediated dilation, NMD; and single passive limb movement, sPLM), as well as BP and heart rate recordings. Measurements were obtained at baseline, after a 6-week control period, and following PS and a follow-up of the same duration. Results No changes occurred following the 6-week control period. After PS, systolic, diastolic, and mean BP decreased by 4.9(SD4.6)% ( P < 0.001, ES = –0.99), 6.9(SD4.9)% ( P < 0.001, ES = –1.43), and 3.7(SD6.2)% ( P = 0.005, ES = –0.63), respectively. Peak Q̇ fem increased by 18.4(SD19.0)% ( P < 0.001, ES = 0.92), and Δ Q̇ fem by 27.1(SD21.7)% ( P < 0.001, ES = 0.98). PWV cf , FMD, NMD, and heart rate remained unchanged. No correlations were retrieved between percentage differences in Q̇ fem and BP variables. Furthermore, all improvements returned to baseline during follow-up. Conclusion These findings indicate that 6-week PS effectively reduces blood pressure in hypertensive patients, possibly due to improved vascular responsiveness in the stretched arteries and the combined effect of other mechanisms that cannot be identified individually. However, these benefits dissipate once the intervention is discontinued.

Source: European Journal of Applied Physiology

DOI: 10.1007/s00421-026-06358-8

Authors: Nicholas Toninelli, Alessandro Maloberti, Emiliano Cè, Cristina Giannattasio, Fabio Esposito

Institutions: University of Milan, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, University of Milano-Bicocca

Language: English

Topic: Cardiovascular Health and Disease Prevention

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,890