Work

Giant cutaneous squamous cell carcinoma in situ with progression to lymph node metastasis

Year: 2026

Type: article

Abstract: Cutaneous squamous cell carcinoma in situ (SCCIS), defined by full-thickness keratinocyte atypia confined to the epidermis without dermal invasion, typically exhibits indolent behavior but may rarely progress to invasive carcinoma, particularly when inadequately treated or long-standing.1 Giant SCCIS is a loosely defined term that may refer to lesions ≥5 to 10 cm in diameter.2,3 These very large lesions of SCCIS are rare and may exhibit increased rates of invasion or metastasis, though prognosis remains poorly defined.

Source: JAAD Case Reports

DOI: 10.1016/j.jdcr.2026.07.019

Authors: Jennifer Rodriguez, Sa Rang Kim, Jeffrey R. Gehlhausen, Sean R. Christensen

Institution: Yale University

Language: English

Topic: Nonmelanoma Skin Cancer Studies

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $750