Work

Xenium in situ spatial transcriptomics of the amygdala and striatum in an α-synuclein preformed-fibril mouse model of Parkinson's disease

Year: 2026

Type: dataset

Abstract: Xenium In Situ spatial transcriptomics data from mouse brain sections in an α-synuclein preformed-fibril (PFF) model of Parkinson's disease, generated to support the study "Tissue Reconstruction with Generative AI" (Yu et al.).Control sections and harvested 3 months post-injection (3MPI) sections cover the amygdala and striatum of the whole sphere of brain. The predesigned 248-gene Xenium Mouse Brain Gene Expression panel was profiled across all sections on the Xenium in situ platform (10x Genomics).

Source: Figshare

DOI: 10.6084/m9.figshare.33017210

Authors: Tingyang Yu, Chanakya Ekbote, Nikita Morozov, Antonio Herrera, Jiashuo Fan, Albert Dominguez Mantes, Salvatore Novello, Hilal A Lashuel, Pascal Frossard, Stéphane d'Ascoli, Gioele La Manno, Maria Brbić

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7169797064

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