Work

Outcomes of patients with Candidozyma auris vs. Candida glabrata and C. krusei : the after-effect of lifetime contact precautions

Year: 2026

Type: article

Abstract: Background: Candidozyma auris, Candida glabrata , and C. krusei are all fungal pathogens intrinsically resistant to azoles. Patient characteristics and outcomes were compared for patients with cultures positive for these three pathogens. Methods: A retrospective cohort study was performed involving patients from an 11 acute care safety net hospital system in New York City. Echinocandin susceptibility rates and patient outcomes, including overall mortality and lengths of hospital stay, were compared for patients with C. auris versus C glabrata/krusei . Results: Resistance to caspofungin was low in all three pathogens. Compared to patients with C. glabrata/C. krusei , patients with C. auris had similar mortality rates. However, compared to patients harboring C. glabrata/C krusei , those with C. auris had longer hospital stays when discharged to a skilled nursing facility, including from the time from culture positivity to discharge (78 ± 148 vs 33 ± 44 d, P = .06). Multivariate regression analysis revealed two factors associated with length of stay: presence of C. auris (P < .001) and hemodialysis (P = .051). Discussion: Echinocandin resistance was unusual, and overall mortality rates were similar, for patients with C. auris, C. glabrata , and C. krusei . However, for patients discharged to skilled nursing facilities, the length of hospital stay was longer for patients with C. auris . The implementation of lifelong contact precautions for C. auris may be an impediment for discharge planning.

Source: Antimicrobial Stewardship & Healthcare Epidemiology

DOI: 10.1017/ash.2026.10789