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Validated Epigenetic and Biological Aging Clocks in Ophthalmology: A Systematic Scoping Review

Year: 2026

Type: preprint

Abstract: This systematic scoping review maps the application of validated epigenetic (DNA-methylation) and biological aging clocks to ocular health and disease, using epigenetic age acceleration as the primary organizing lens. It charts which clocks, tissues, ocular diseases, exposure constructs, and study designs have been studied; describes the direction and consistency of reported associations without pooling; and identifies evidence gaps and a research agenda. Conducted per PRISMA-ScR (Tricco 2018) using the Arksey & O'Malley / Levac / JBI framework. No effect hypothesis is tested; the deliverable is a comprehensive evidence map.

DOI: 10.17605/osf.io/c9bvg

Author: Sirawich Chaiparnich

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7169810060

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