Chemical‐Sensing Catheters for Long‐Term and Personalized Therapeutic Management
Year: 2026
Type: article
Abstract: Long-term intravenous catheterization is vital for delivering chemotherapy to cancer patients and parenteral nutrition to those with intestinal failure, but it inevitably leads to complications, including metabolic disorders, bloodstream infection, liver injury, and kidney injury. Clinical monitoring methods show notable delays, while real-time blood monitoring devices fail to ensure long-term stability in vivo. Here, we present a chemical-sensing catheter that integrates multiple analyte sensors, including creatinine, taurocholic acid, bilirubin, and taurine, for real-time monitoring of complications in patients receiving long-term chemotherapy or parenteral nutrition in situ. The design of the metalgel preserves signal integrity through 1 million bending deformations, and a dual-network molecularly imprinted polymer suppresses in vivo performance degradation, enabling stable long-term operation of the chemical-sensing catheter over a 3 month implantation period. In chemotherapy and parenteral nutrition applications, early monitoring of liver and kidney injury, combined with prognostic intervention, mitigates risks such as bile stasis, hepatitis, and hepatic steatosis. With the integration of machine learning analysis of multimodal sensor data, this technology provides early prediction of complications and establishes a new paradigm for personalized therapeutic management.
Source: Advanced Materials
DOI: 10.1002/adma.74221
Authors: Yiran Li, Xinyin Cao, Qianming Li, Xinyu Liu, Haifeng Sun, Yiding Jiao, Guanheng Huang, Linfeng Han, Jiang Lu, Kuangyi Zou, Dan Li, Wenxuan Guo, Tingting Ye, Jiacheng Wang, Er He, Fangyan Li, Yuanzhen Wang, Shuo Yang, Chenyu Bai, Jie Song, Xusong Li, Hanting Zhang, Haidong Wang, Yuxia Zhang, Yuxia Zhang, Ye Zhang, Ye Zhang
Institutions: Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructures, Nanjing University, First Affiliated Hospital of Zhengzhou University, University of Electronic Science and Technology of China, Nanjing University of Chinese Medicine, Nankai University
Language: English
Subfield: Bioengineering
Field: Chemical Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7170032768