Sex-Specific Landscapes of Crossover and Noncrossover Recombination in Coppery Titi Monkeys ( Plecturocebus cupreus )
Year: 2026
Type: article
Abstract: Along with germline mutations, meiotic recombination plays a fundamental role in shaping genetic diversity and thus directly influences a species' potential adaptive response to environmental change, amongst other features. Despite the recombination landscape being of central importance for a variety of questions in molecular evolution, the genome-wide distribution and frequency of recombination remains to be elucidated in many nonhuman primate species. Utilizing novel high-coverage genomic data from three multi-sibling families, we here provide the first estimates of the rates and patterns of crossover and noncrossover recombination in coppery titi monkeys (Plecturocebus cupreus)-a socially monogamous, pair-bonded primate that serves as an important model in behavioral research. Consistent with haplorrhines, crossover and noncrossover recombination in this platyrrhine are frequently localized at PRDM9-mediated hotspots, characterized by a 15-mer binding motif with substantial similarities to the degenerate 13-mer motif found in humans. The sex-averaged crossover rate in coppery titi monkeys is comparable with those of other primates; however, no significant difference in recombination rates was observed between the sexes, despite a pronounced maternal age effect in the species. Similarities also exist with regards to the sex-specific genomic distribution of noncrossover events, though the minimal conversion tract lengths of extended events was observed to be considerably longer in maternally inherited noncrossovers. Taken together, these similarities and differences in the recombination landscape relative to other primates highlight the importance of incorporating species-specific rates and patterns in evolutionary models, and the resources provided here will thus serve to aid future studies in this important primate model system.
Source: Genome Biology and Evolution
DOI: 10.1093/gbe/evag186
Institutions: Arizona State University, University of California, Davis
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,850
Funders: National Science Foundation, Arizona State University, National Institutes of Health, University of California, Davis, National Institute of Mental Health, National Institute of General Medical Sciences, National Institute of Child Health and Human Development, California National Primate Research Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Genome Center, University of California, Davis
Awards: G3256101227, G3304377175, Acquisition of Covaris E220 and Sciclone G3 systems for high throughput sequencin, CAREER: Characterizing the rates and patterns of mutation and recombination in Old and New World monkeys, G4704198146, G590635114, G6671297155, THE NEURAL BASIS OF PAIR-BONDING IN FEMALE TITI MONKEYS, G791781759, California National Primate Research Center, Characterizing the full spectrum of genomic variation in biomedically-relevant primates, Kappa opioid and oxytocin interactions in social buffering and separation, On differentiating selective and neutral evolutionary processes
OpenAlex ID: W7170036957