Work

Dupilumab as a targeted therapeutic strategy for Th2-driven cutaneous manifestations in Kimura disease

Year: 2026

Type: article

Abstract: Dear Editor, Kimura disease (KD) is a rare, chronic inflammatory condition characterized by subcutaneous nodules, lymphadenopathy, peripheral and tissue eosinophilia, and markedly elevated serum IgE concentrations. Although its precise etiopathogenesis remains incompletely defined, accumulating evidence supports its classification as a type 2 immune-mediated disorder, sustained by Th2 lymphocyte activation and overexpression of interleukin (IL)-4 and IL-13 signaling pathways. This immunological milieu promotes eosinophilic infiltration, vascular proliferation, IgE overproduction, and persistent pruritus, ultimately driving both systemic and cutaneous manifestations of the disease. [...].

Source: Dermatology Reports

DOI: 10.4081/dr.2026.10839

Authors: Gaetano Licata, Anna Balato, Giuseppe Argenziano, Caterina Mariarosaria Giorgio

Institution: University of Campania "Luigi Vanvitelli"

Language: English

Topic: Vascular Tumors and Angiosarcomas

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $539