Work

Lipids in ovarian cancer ascites impair T cell activation by disrupting TCR dynamics

Year: 2026

Type: article

Source: Nature Metabolism

DOI: 10.1038/s42255-026-01557-1

Authors: Erica G. Brown, Ewoud B. Compeer, Zhiyang Gan, Andre R. Kelly, Alexander A. Shestov, Laura Córdoba-Espejo, Mitchell T. Evans, Alan Y. Liu, Noelle H. Naughton, Tanay S. Parnaik, Jemma H. Larson, Bruce R. Blazar, Caroline R. Bartman, Joshua D. Rabinowitz, Michael L. Dustin, Daniel J. Powell, Roddy S. O’Connor

Institutions: University of Pennsylvania, Chinese Academy of Medical Sciences & Peking Union Medical College, University of Oxford, Kennedy Institute of Rheumatology, Spanish National Cancer Research Centre, University of Minnesota, Ludwig Cancer Research, Princeton University, Ludwig Cancer Research

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute

Awards: G1028086129, Phase I clinical trial of adoptive transfer of autologous folate receptor-alpha redirected CAR T cells for ovarian cancer, What fuels CAR T-cell serial killing, Mechanisms and Therapy of Chronic Graft-vs.-Host Disease

OpenAlex ID: W7170074956

FWCI: 2.638

Cites: 70

Cited by: 1

Related to: 10