Work

Nephron-Sparing Surgery for Unilateral Non-Syndromic Wilms Tumor in a 9-Day-Old Neonate

Year: 2026

Type: article

Abstract: Neonatal renal tumors are uncommon and generally associated with an excellent prognosis. We report the youngest patient to date with unilateral non-syndromic Wilms tumor successfully treated with nephron-sparing surgery rather than radical nephrectomy, which is the current standard of care. The patient subsequently received risk-adapted chemotherapy. At 18 months of follow-up, he remains asymptomatic and with symmetric differential renal volumes, consistent with preserved bilateral renal function. This case suggests that nephron-sparing surgery, when technically feasible, may represent a safe and effective treatment option for carefully selected neonatal renal tumors, offering a functional advantage over radical nephrectomy without compromising oncologic safety.

Source: Children

DOI: 10.3390/children13070966

Authors: Silvia Ceccanti, Francesco Morini, Loredana Amoroso, Gian Marco Andreoli, Gabriele Masselli, Denis A. Cozzi

Institutions: Policlinico Umberto I, Sapienza University of Rome

Language: English

Topic: Renal and related cancers

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,896