Xanthoceras sorbifolium Bunge Leaf Extract Ameliorates Diabetic Nephropathy Through Coordinated Metabolic Reprogramming and Inflammatory Signaling
Year: 2026
Type: article
Abstract: Bunge leaf extract (XBL) has shown promising bioactivities, but its active components and mechanisms are not well understood. In this study, a comprehensive investigation including chemical profiling, network pharmacology, in vivo validation, and renal multi-omics was conducted. The results show a diverse composition dominated by flavonoids, which were identified as key bioactive contributors. In the streptozotocin-induced DN rat model, XBL administration significantly improved metabolic disorders and renal injury. Integrated metabolomic and transcriptomic analyses demonstrated that XBL alleviates DN by coordinately regulating metabolic reprogramming and inflammation-related signaling pathways. Additionally, representative flavonoids showed α-glucosidase inhibitory activity, supporting their potential role in glucose metabolic regulation. The results from this study suggest that XBL is a promising functional food ingredient for DN intervention.
Source: Foods
Authors: Mengting Han, Xianyu Zhang, Yiqing Jia, Yifei Zhang, Zijin Qin, Shuyu Zhou, Zhe Xu, Hui Zhou
Institutions: Dalian Minzu University, University of Georgia
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Award: G4911152003
OpenAlex ID: W7170083254
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