Work

Coupled mitochondrial and endoplasmic reticulum membrane failure in Parkinson's disease

Year: 2026

Type: preprint

Abstract: Parkinson's disease is usually framed as a dopaminergic and α-synuclein disorder. We propose, as a testable hypothesis, that vulnerable nigral neurons enter disease through coupled physical-state failure of the mitochondrial inner membrane and endoplasmic reticulum, disrupting coenzyme Q10 diffusion, protein import, ER folding, and integrated-stress signalling. The model makes falsifiable biophysical predictions and motivates pharmacological paraoxonase-2 modulation as one therapeutic probe.

Source: Zenodo (CERN European Organization for Nuclear Research)

Authors: JUNG, SUNGSOO, Lee, Chun Geun

Institutions: Soonchunhyang University Hospital Bucheon, Brown University

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7170180727

Cites: 2

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