Work

Dietary Fat Shapes Bile Acid-Insulin Coupling in Adults With Obesity

Year: 2026

Type: article

Abstract: Objectives: Diet shapes the bile acid (BA) pool through host and microbial biotransformation, altering the primary/secondary balance, 12α-hydroxylation, and conjugation patterns. Distinct BA species differentially influence insulin secretion via FXR and TGR5 signaling.

Source: Current Developments in Nutrition

DOI: 10.1016/j.cdnut.2026.108002

Authors: Nicole Southey, Marahi Perez-Tamayo, Jason M Ridlon, Nicholas Burd, Ruoqing Zhu, Hannah D Holscher

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,000