The vagus nerve promotes memory in rats via nutrient-induced septo-hippocampal acetylcholine signaling
Year: 2026
Type: dataset
Abstract: Data included in this manuscript include immunohistochemical analyses and western blotting to assess protein expression, acetylcholine release readings using fiber photometry and intensity-based fluorescent acetylcholine reporters, and animal behavior readings analyzed using AnyMaze software. Animal treatments conducted include medial septum cholinergic neuron ablation using direct 192 IgG saponin immunomoxin infusion, sub-diaphragmatic vagotomy, and chronic early life exposure to our obesogenic diet model. Food and nutrient consumption readings were collected manually, as well as using the BioDAQ, which is an automated ingestive behavior system. Fiber photometry data were collected using Bonsai software, and subsequently analyzed and plotted using custom-built MATLAB code and Graphpad Prism. All other data were analyzed and plotted using GraphPad Prism.
Source: Figshare
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7170401526