Work

Higher Saturated Fat Intake Associated With Increased Binding of sIgA to Pro-inflammatory Gut Bacteria in Healthy Adults

Year: 2026

Type: article

Abstract: Objectives: We previously showed that elevated fecal sIgA was associated with lower total Healthy Eating Index (HEI) scores, higher gut (calprotectin, myeloperoxidase) and systemic (white blood cell ct.) inflammation, and bacteria with inflammatory potential (i.e. Escherichia coli). The objectives of this study were (1) to determine whether specific dietary components drive the association between sIgA and HEI, (2) whether microbes positively correlated with total sIgA are bound to sIgA and (3) whether sIgA-microbe binding patterns vary between participants with high and low fecal sIgA.

Source: Current Developments in Nutrition

DOI: 10.1016/j.cdnut.2026.109020

Authors: Nithya Krishnakumar, Zeynep Alkan, Priya Chanda, Danielle G Lemay, Andrew Oliver

Institutions: University of California, Davis, Agricultural Research Service, United States Department of Agriculture, Western Human Nutrition Research Center

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,000