Work

Enhanced Anti-Inflammatory Activity of Anthocyanin-Derived Pigments Under Hypoxic Conditions In Vitro

Year: 2026

Type: article

Abstract: Objectives: Inflammation contributes to many chronic diseases and cancer progression through cytokine-driven signaling pathways, including hypoxia-induced activation of NF-kB and interleukin-11 (IL-11). Anthocyanins (ACNs), plant polyphenols, can modulate these pathways but are chemically unstable. Pyranoanthocyanins (PACNs) derived from ACNs are more stable, but their biological activity is understudied. Here we compared anti-inflammatory effects of ACNs and PACNs in experimentally induced in-vitro hypoxic conditions by assessing NF-kB activation and IL-11 suppression.

Source: Current Developments in Nutrition

DOI: 10.1016/j.cdnut.2026.108241

Authors: Harmeen Prasher, Monica Giusti, Patrick Sellers, Ouliana Ziouzenkova

Institution: The Ohio State University

Language: English

Topic: Phytochemicals and Antioxidant Activities

Subfield: Biochemistry

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,000