Work

De Novo Lipogenesis Is Increased in Adolescents With Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease

Year: 2026

Type: article

Abstract: Objectives: In adults with metabolic dysfunction-associated steatotic liver disease (MASLD), de novo lipogenesis (DNL) is increased and contributes to disease pathology. MASLD is present in nearly 40% of adolescents with obesity, but the role of DNL in this population is not established. Disease progression is faster in adolescents than adults and there are differences in liver histology, supporting the need for studies in young people so that age-appropriate treatment strategies can be developed.

Source: Current Developments in Nutrition

DOI: 10.1016/j.cdnut.2026.107929

Authors: Kevin R Short, Sirish K Palle, Jessica G George, Youngsil Kim, Jacob E Friedman, Elizabeth J Parks

Institutions: University of Oklahoma, University of Missouri

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,000