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Multifunctional LA and PTMC coating for biliary stents to combat cholangiocarcinoma proliferation in obstruction

Year: 2026
Type: article
Abstract: Licorice-derived licochalcone A (LA) has antitumor effects, while conventional PTMC-coated biliary stents relieve malignant biliary obstruction but lack tumor-suppressive function and suffer from in-stent restenosis. This study fabricated an LA-loaded PTMC composite stent coating via favorable material compatibility for local sustained drug delivery. The coating improves surface hydrophobicity, enables stable LA release and good biocompatibility, and efficiently inhibits cholangiocarcinoma and colorectal cancer cell growth and tumor progression. LA exerts antitumor activity by regulating the CYP19A1-mediated GPR30-AKT pathway. This dual-functional coating offers a feasible strategy for clinical biliary stent modification and local tumor intervention.
Source: iScience
DOI: 10.1016/j.isci.2026.116093
Authors: Liang Jin, Yaoting Wang, Yaohui Liu, Qianping Mao, Ben Feng, Jiaxing Xin, Yumei Zhang, Lan Li, Xiaodan Guan, Xiaolong Wu, Zhengtao Wang, Li Yu, Ling Zhang, Rui Zan
Institutions: Zhejiang Chinese Medical University, Shanghai Jiao Tong University, Shanghai University of Traditional Chinese Medicine, RWTH Aachen University, Tongji University, Shanghai East Hospital, Fudan University
Language: English
Open Access status: gold
Estimated APC paid: $3,240
OpenAlex ID: W7170784676
FWCI:
Cites: 39
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