Work

Protective Effects of OMT-28, a Stable Analog of 17,18-EEQ, Against Lipopolysaccharide-Induced Suppression of Adipogenic and Thermogenic Genes in Murine Brown Adipocytes

Year: 2026

Type: article

Abstract: Objectives: Brown adipose tissue, recognized for its role in non-shivering thermogenesis, has emerged as a promising target for combating obesity. Previous studies have demonstrated that inflammation suppresses brown adipocyte differentiation and thermogenic function. Moreover, 17,18-epoxyeicosatetraenoic acid (17,18-EEQ), an epoxide metabolite of eicosapentaenoic acid, has been demonstrated to exhibit anti-inflammatory properties. However, 17,18-EEQ’s beneficial effects are often limited by its chemical and metabolic instability.

Source: Current Developments in Nutrition

DOI: 10.1016/j.cdnut.2026.109118