Work

Circadian clock and its potential as a therapy for ischemic heart disease

Year: 2026

Type: article

Abstract: According to an epidemiological survey, myocardial infarction, ischemia–reperfusion injury, and aortic rupture usually occur in the morning and summer and are characterized by more severe symptoms and poorer prognosis. The occurrence, development, treatment difficulties, and poor prognosis of ischemic heart disease are closely related to circadian rhythm disorders and the abnormal transcription of circadian clock genes. Normal circadian rhythms regulate neurohumoral regulation and energy metabolism, thereby playing a protective or modulatory role in ischemic heart disease (IHD). HIF1α links the IHD and circadian signaling pathways through the hypoxia response element (HRE) and Per-Arnt-Sim (PAS) domains in gene promoters and enhancers.

Source: Cell Communication and Signaling

DOI: 10.1186/s12964-026-03073-x

Authors: Yiran Wang, He Wang, Ning Liu, Jiayi Zhang, Bin Liu

Institutions: Jilin University, Second Affiliated Hospital of Jilin University, First Hospital of Jilin University

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,390