Work

Urolithin A, a Gut Metabolite of Ellagic Acid, Reduces Fat Accumulation by Decreasing Food Intake and Upregulating Energy Expenditure in Caenorhabditis elegans

Year: 2026

Type: article

Abstract: Objectives: Polyphenolic substances, ellagitannins and ellagic acid, are abundant in foods such as pomegranates and berries, and can be converted to urolithin A by gut bacteria. Previously, the health-promoting effects of urolithin A were reported, including reductions in body weight and hepatic lipid levels via AMP-activated protein kinase (AMPK)-dependent mechanisms from in vivo and in vitro models. However, the direct effects of urolithin A on other mediators of lipid metabolism, such as food intake and energy expenditure, remains unclear.

Source: Current Developments in Nutrition

DOI: 10.1016/j.cdnut.2026.108282

Authors: Yeonhwa Park, Zixuan Teng, Tung Phan, Jun Xiao, Soonkyu Chung

Institution: University of Massachusetts Amherst

Language: English

Topic: Pomegranate: compositions and health benefits

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,000