Work

Durable antiviral protection via direct in vivo programming of hematopoietic stem cells

Year: 2026

Type: article

Abstract: Efforts to achieve durable control or eradication of HIV-1 have increasingly turned toward gene-based strategies potentially capable of providing long-term protection. In this context, a new study by Li et al.1 presents a notable conceptual advancement: the direct in vivo genetic programming of hematopoietic stem cells (HSCs) to generate a systemic source of antiviral biologics. By exploring helper-dependent adenoviral vectors (HDAd), the authors bypass the logistical and biological constraints associated with ex vivo HSC manipulation.

Source: Molecular Therapy Advances

DOI: 10.1016/j.omta.2026.201814

Author: Anja Ehrhardt

Institution: Witten/Herdecke University

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Deutsche Forschungsgemeinschaft