Work

Long-term Outcomes of Endoscopic and Surgical Resection for High-risk pT1 Colorectal Cancer in Elderly Patients

Year: 2026

Type: article

Abstract: Objectives: Surgical resection (SR) is recommended for pT1 colorectal cancer (CRC) with high-risk histological features for lymph node metastasis. However, endoscopic resection (ER) alone without additional SR is sometimes chosen for elderly patients due to surgical tolerance. Comparative studies on outcomes and prognosis between ER and SR remain limited. Methods: This retrospective study evaluated the outcomes of ER alone or SR in elderly patients (≥80 years) with high-risk pT1 CRC between 2008 and 2021. Results: = 0.12). PNI <43.4 was identified as a prognostic risk factor, and in the ER group, patients with low PNI showed significantly worse survival. Conclusion: There was no significant difference between the outcomes of ER alone and SR among elderly patients with high-risk pT1 CRC. PNI can be a valuable predictor of prognosis in the ER group.

Source: Journal of the Anus Rectum and Colon

DOI: 10.23922/jarc.2025-095