[Clinicopathological and molecular features of acquired cystic kidney disease and associated renal cell carcinoma].
Year: 2026
Type: article
Study design: Case Report
Abstract: OBJECTIVE: To investigate the clinicopathological and genetic features of acquired cystic kidney disease (ACKD) and secondary renal cell carcinoma (RCC) in end-stage renal disease (ESRD) patients undergoing dialysis. METHODS: The clinicopathological data of 9 patients with ACKD, of whom, 7 had concurrent RCC, of the Department of Pathology, Peking University Third Hospital from 2020 to 2025 were retrospectively analyzed. Immunohistochemistry (IHC) and next-generation sequencing (NGS) were used to detect RCC-related proteins and targeted-drug associated gene variations/microsatellite instability (MSI) status. RESULTS: deletion in one ACKD-RCC patient and the pRCC patient, which were accompanied by marked necrosis and pT3a staging. The RCC patients were regularly followed up for 1-32 months postoperatively without additional treatment, and no recurrence or metastasis was observed. CONCLUSION: (Tier Ⅱ) variants in 2 RCC patients, respectively, accompanied by coagulative necrosis and advanced pathological stage, which may indicate a poor prognosis. This study suggests that imaging screening for RCC should be strengthened in young and middle-aged male ESRD patients with long-term dialysis, and adequate sample examination should be performed to detect potentially precancerous lesions, such as atypical renal cysts. The prognosis of ACKD-RCC requires comprehensive analysis combining clinicopathological and molecular genetic features.
Source: PubMed
Authors: Haijing Liu, Wenyang Guo, Shunan Shi, Huiying He
Institutions: Peking University, Peking University Third Hospital
Language: Chinese
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7170988782